Rosemary plant extract as a natural anti-oxidant is 4 times stronger than synthetic anti-oxidant like BHT and BHA. For this reason, it has been under attention not only for its anti-oxidant properties rather for its anti-inflammatory, anti-tumor, anti-bacterial, and anti-virus properties in different studies. This research investigates the effects of temperature, time, pH, and substance concentration in the labeling of irradiated rosmarinic Acid by radioisotope gallium-67 as a high-resolution imaging agent for SPECT imaging. In this study, gamma irradiated rosmarinic Acid nanoparticles at 20 kGy and 30 kGy levels in two concentrations of 0.5 and 1% were radiolabeled by gallium-67 radioisotope produced in Karaj cyclotron, and their efficiency and radiochemical purity were compared. Labeling conditions (including pH, temperature, time, and compound concentration) were investigated. Quality control was performed by thin-layer chromatography (RTLC). Resulting from the experiments, 30 kGy level and 1% concentration at 45 °C for 30 minutes at pH = 5.5-6 proved to be the best time for labeling rosemary nanoparticles, and the highest radiochemical purity achieved was 95%; radio conjugate also showed good stability after 12 hours.

Introduction: Hemophilia is one of the most important coagulation disorders. At the present time the current treatment is factor replacement which may lead to many socio-economic problems and also transmission of some viral infections. In this study we evaluate an alternative treatment to factor replacement to decrease the aforementioned problems. Material and Methods: This was an interventional study and the statistical population included all Hemophilia patients that referred to Besat Hospital. They were randomly divided into two groups: an intervention group of 13 patients and a control group of 15 patients. Tranexamic Acid was only used for the intervention group (15 patients). Then the data was assessed by spss win software. Results: In the intervention group bleeding episodes were reduced significantly (from 4.07 episodes per month to 3 episodes per month) and so was the need for factor replacement (from 80.1 u/kg/m to 58.7 u/kg/m). In the control group bleeding episodes and the need for factor replacement did not differ prior to and during the study. Conclusion: The results of this study showed that daily prophylactic use of TEA is effective in reducing bleeding episodes and decreasing the need for factor replacement in hemophilia patients. However, due to increased PTT and decreased serum clotting factors in patients, the risk of life threatening bleeding is likely to be high. Thus we don’t recommend the use of TEA as a prophylactic measure in hemophilia.  

Background and Objective: Textile wastewaters are known as an important environmental pollutant. The main characteristic of textile wastewater is its colorness, which contains various organic and inorganic pollutants. Therefore it is necessary to treat such effluent effectively before discharging into the environment.Methods: In a fundamental-applicable study, removal efficiency of Acid red 18 and Acid red 14 using zero valent iron powder has been investigated. Parameters studied include pH (3-11), contact time (15-120 min), and initial concentration of iron powder (0.5-2 g/L).Results: Batch experiments show that dye removal was increased with increasing mass of iron powder and contact time, while decreased with increasing of pH. The high removal efficiency was observed in pH=3, contact time=120 min and iron powder concentration of 2 g/L. The result of kinetic studies shows that removal of Acid red 18 and Acid red 14 was best described by pseudo-second order kinetic model.Conclusion: the overall results of present work shows efficient removal of Acid red 18 and Acid 14 by zero valent iron powder.

Background: Tetralogy of Fallot (TOF) refers to a condition in which left ventricular volume is normal or slightly less than normal. Given the differences observed in some Asian patients with TOF، the present study was conducted to investigate left heart by determining Z-scores for the mitral valve in Iranian patients with TOF. Methods: Eligible subjects in this prospective descriptive study comprised all patients with TOF presenting to Shahid Modarres Hospital in Tehran from March 2012 to March 2015 and diagnosed as the candidates for surgery. After determining the need for surgery and the therapeutic method required، the mitral valve size and Z-scores were calculated. We analyzed sex، age، body surface area (BSA)، mitral size (in 2-chamber and 4-chamber view)، mitral Z-score، other cardiac anomalies، number of surgery and previous surgery. Results: Of a total of 80 patients included in the study over 3 years، 29 (36. 3%) were male and 51 (63. 8%) were female. The mean age of the patients was 7. 15± 3. 37 years and their mitral size was found to be 10-27 mm (16. 2± 5. 99 mm) using echocardiography. Z-scores of the mitral valve were also obtained as-3. 09± 2. 11، ranging between-7. 1 SD and +1. 3 SD. 58 (72. 5%) patients have only TOF and 22 (27. 5%) with other cardiac anomalies. 45 patients were for first time underwent surgery and 22 patients for second time، 12 patients for three time and 1 for forth. Of a total of 35 patients had previous surgery، the most common were shunt 15 (42. 9%) and then tetralogy of Fallot total correction (TFTC) in 12 (34. 3%). Of a total of 80 patients، 59 (73. 8%) underwent TFTC، 17 (21. 3%) under pulmonary valve replacement and 4 (5%) shunt. Conclusion: Z-scores of the mitral valve were found to be significantly below the normal Value، (i. e. 0± 2 SD)، in the study patients، suggesting the risk of hypoplastic left heart syndrome in Iranian patients with TOF، nevertheless، the type of TOF examined in these patients might have been different from those observed in other races and regions.

Application and interpretation of statistical significance of association are the basic and necessary principle in medical research. Traditionally, hypothesis testing and reporting p-Values are widely used to quantify the statistical significance of observed results. In the last two decades, the calculation of a p-Value in research and especially the use of a threshold to declare the statistical significance of the p-Value have been challenged. The limitations of p-Value, such as the dependence of its Value on the sample size and not reflecting the clinical significance, have been repeatedly mentioned. The statisticians and methodologists recommend do not report p-Value alone, and reporting of effect size index with corresponding confidence interval is mandatory. However, many researchers do not pay attention to this and do not even interpret the p-Value correctly. The present study intended, to provide an integrated instruction for reporting the statistical and clinical significance in medical sciences with the approach of hypothesis testing (reporting p-Value).

Wastewater from the textile industry, especially that containing azo compounds, often contains toxic materials that persist in the environment. Therefore, it is necessary to evaluate the performance of various methods for their removal. Acid red 37 combinations represent a single structure in the azo dyes which have already been widely used in the textile industry. The purpose this study is the optimization of effective factors and investigation performance of the electrofenton and electrocoagulation methods in synthetic wastewater for Acid Red 37 dye removal from aqueous solutions. In this study, synthetic wastewater was formed from Acid Red 37 dye and pilot Scale and the concentration, pH, electrical density and temperature parameters were investigated. Ultimately the optimum conditions were determined as well as the amount of energy consumption at 90 percent efficiency. To investigate the pollutant degradation GC-Mass was used and the results show that both methods had the ability to remove Acid Red 37. Electrocoagulation was found to be more efficient than the electrofenton method; respectively, the optimum conditions for removal by the electrofenton and electrocoagulation methods were pH=3, time=120 min, density- 30 mA.cm2, concentration=50 mg/L, consumption energy 142.8 KWh/Kg Dye and pH=7 time=120 min, density- 30 mA.cm2, concentration=150 mg/L, consumption energy 130.2 KWh/Kg Dye. These results show that the electrocoagulation method was better than electrofenton with its high ability for removal Acid Red 37.